Several years later, two additional ESR1 fusions, ESR1-e2 fusion with the acidic residue methyltransferase 1 gene, C6orf211/ARMT1 (ESR1-e2>C6orf211/ARMT1) and ESR1-e6 fusion with a-kinase anchoring protein 12 gene, AKAP12 (ESR1-e6>AKAP12) were identified in AI resistant breast cancer by Giltnane and colleagues (Table 1) (82) with no functional data available (Table 1). This evidence concerns the gene ESR1 and breast cancer.