The heterogeneity in efficacy among the subgroups, especially given that polatuzumab vedotin targets a surface marker ubiquitously expressed on mature B-cell lymphomas, underscores that more information is needed to determine which patients will most benefit from pola-R-CHP and if any subgroups (double and triple hit, for example) may actually fare worse. Here, POLA1 is linked to B-cell non-Hodgkin lymphoma.