Tumor cells deceive NK cells in several ways: a) by increasing human leukocyte antigen E (HLA-E) (8) and HLA-G (9); b) via inhibitory immune checkpoints (10); c) decreasing cytokine expression (11); d) decreasing NK cell apoptotic activity (12); e) reducing expression of activating receptors on NK cells (13); f) increasing the expression of prostaglandin E2 by tumor-associated fibroblasts (14). This evidence concerns the gene HLA-E and neoplasm.