The third group of NF2-wild type tumors predominantly lacked NF2 mutations and were split further into 3 subgroups: those containing chromatin regulator mutations in BAP1 or PBRM1, skull-based meningiomas with AKT1, PIK3CA, and SMO mutations, and meningiomas with a mix of mutations that shared no discernable pattern (68). The gene discussed is SMO; the disease is meningioma.