Indeed, ATRX mutations extend into young adulthood and occur at high frequency in adult low grade gliomas (13, 61), as well as other cancers such as pancreatic neuroendocrine tumors (62), pediatric osteosarcomas (63), sarcomas (64–66), pheochromocytomas and paragangliomas (67, 68). Here, ATRX is linked to glioma.