For example, consumption of GRB7 inhibits cell proliferation through the ERK/pathway, promotes apoptosis and reduces tumor xenografts (29); GRB7 is up-regulated during TC development, and regulates TC cell proliferation, cell cycle and mitochondrial apoptosis by activating the MAPK/ERK pathway (30); GRB7 participates in the activation of ERK and Ras by aquaporin-1 to promote the proliferation and invasion of gastric cancer cells (11). Here, AQP1 is linked to neoplasm.