METTL3 and neoplasm: We first compared the expression levels of 19 m6A regulator genes between 375 primary tumor samples and 32 solid tissue samples; most of these genes showed higher expression in tumor samples than normal samples, including HNRNPA2B1, HNRNPC, IGF2BP1, IGF2BP2, IGF2BP2, KIAA1429, METTL3, RBM15, YTHDF1, YTHDF2, and ZC3H13, but the expression level of ALKBH5 was opposite (Figures 2A, B).