However, inflammatory cells produce tumor necrosis factor-α, transforming growth factor-β, interleukin-6 (IL-6), and other cytokines, which regulate the transcription factor NF-κB and the signal transducer and activator of transcription-3 (STAT3) pathways, and promote tumor cell metastasis (28–30). This evidence concerns the gene NFKB1 and neoplasm.