RNF182, a member of RING E3 ubiquitin ligase family, has previously been reported to associate with innate immune system (31), cancers (20), Alzheimer’s disease (32), ischemia-reperfusion injury (33) and various biological functions such as nuclear factor-kappa B (NF-κB) (31)and apoptosis (34). This evidence concerns the gene RNF182 and early-onset autosomal dominant Alzheimer disease.