RNF182 and non-small cell lung carcinoma: To identify the potential RING finger protein family member that contributes to Bap-induced NSCLC, we analyzed the relative expression of RING finger protein family member in GEO database (GSE19510) of gene expression profiles of lung fibroblasts cells WI-38 (17), and found that RNF182 was significantly downregulated by BPDE in a dose-dependent way (Figures 1A, B).