Water-soluble rapamycin analogues (temsirolimus, everolimus), ATP-competitive mTOR inhibitors (MLN0128, AZD2014, PP242), and dual PI3K/mTOR inhibitors (NVP-BEZ235, LY3023414, PQR309, XH00230381967, SN20229799306, GSK2126458, PKI-587) have been used to treat a variety of cancers (246). Here, MTOR is linked to cancer.