In hepatocellular carcinoma cells, LDHA is overexpressed due to downregulation of miR-383, triggering increased cell proliferation, invasion and glycolysis (55), MYC, NFκB, HIF-1α-mediated signaling enhances glycolysis in HCC by promoting upregulation of LDHA (56–58). This evidence concerns the gene MYC and hepatocellular carcinoma.