Small-molecule GLUT1 inhibitors such as the natural products Resveratrol (227, 228), Quercetin (229, 230), Kaempferol (231) and Curcumin (232), and the non-natural products WZB117 (233, 234), STF‐31 (235, 236), BAY-876 (237), NV-5440 (238) can effectively inhibit the progression of various cancers including HCC. Here, SLC2A1 is linked to hepatocellular carcinoma.