IL4 and neoplasm: One is pro-inflammatory M1 macrophage and another one is anti-inflammatory M2 macrophages, which are controlled and regulated by prostaglandin E2 (PE2), TGF-β, IL-4, IL-10, and IL-13, and involved in tumor-promoting activities by secreting anti-inflammatory cytokines such as TGF-β and IL-10 (40).