Activation of CAFs by inhibiting different signaling pathways including nuclear factor kappa B (NF-kβ), C-X-C chemokine receptor 4 (CXCR4), fibroblast growth factor receptor (FGFR), and Hedgehog using selective inhibitors showed tumor suppressive or antitumor activity (52). Here, CXCR4 is linked to neoplasm.