CAFs stimulate the release of cytokines and growth factors including platelet derived growth factor (PDGF), VEGF, hepatocyte growth factor (HGF), stromal cell-derived factor 1 (SDF1), and so on, which activates endothelial cells, resulting in an enhancement of tumor growth, angiogenesis process, and tumor vasculature. This evidence concerns the gene CXCL12 and neoplasm.