Several studies showed that using inhibitors or neutralizing antibodies against tumor-derived factors like as IL-6, colony stimulating factor 1 (CSF1), and granulocyte-macrophage-colony stimulating factor (GM-CSF) and chemokines such as CXCR2, CXCR4, CC chemokine ligand 2 (CCL2) suppress MDSCs expansion and recruitment (55–59). This evidence concerns the gene CXCR4 and neoplasm.