CCNE2 and cancer: Adiponectin induces cell cycle arrest and apoptosis, increases the expression of the proapoptotic genes BAD (BCL2-associated agonist of cell death) and TP53 (tumor protein p53), decreases the antiapoptotic gene BCL2, and reduces the expression of CCND1 (cyclin D1) and CCNE2 (cyclin E2) in breast cancer cells, thereby inhibiting growth, invasion, and migration and inducing apoptosis of cancer cells (43).