Silibinin has the effect of soothing the liver and relieving depression, clearing heat and detoxifying, enhancing the gallbladder, dispelling dampness, and a variety of anti-tumor activities, can eliminate CSC and reduce EMT by reducing the expression of N-cadherin and reducing EMT-related markers to prevent rectal cancer (144), and can also affect tumors through the JAK2/STAT3 pathway the ability of the tissue to migrate and invade (145). Here, STAT3 is linked to rectal cancer.