Atractylenolide III is a kind of anti-inflammatory and anti-tumor active substance, that induces apoptosis of human colon cancer HCT-116 cells by promoting apoptosis-related genes, regulating the Bax/Bcl-2 apoptosis signaling pathway, and the expression of caspase-3 and p53 (41). Here, BCL2 is linked to malignant colon neoplasm.