Notably, curcumin can inhibit the proliferation and invasion of cervical cancer cells by impairing the NF-kB signaling pathway (103), and its derivatives inhibit STAT3 which in turn inhibits breast tumor cell growth, angiogenesis, and metastasis, and induces TAM by M2-type transformation to M1-type, to achieve anti-tumor effect (104). The gene discussed is NFKB1; the disease is neoplasm.