The nucleoside erythroid-2-related factor 2 (Nrf2), a nuclear factor that maintains CSC survival and anti-stress, can be regulated by Brusatol from the mature seeds of brucei Chinensis and the extract of brucei japonica can inhibit the surface marker CD133 of CSC in hepatoma cells and EpCAM expression (147, 148). This evidence concerns the gene PROM1 and hepatocellular carcinoma.