CASP3 and brain ischemia: Modern pharmacological studies have shown that hyperoside has strong analgesia, protection of heart, brain, and liver, anti-myocardial hypoxia injury, and protection of cerebral ischemia injury, etc, one of the flavonoid glycosides, increases the levels of Bcl-2 and cleaved caspase-3 (caspase-3) in breast cancer cell lines and subcutaneous allograft mouse models high, which reduces the level of Bax and induces apoptosis (26).