Among them IL-1, IL-6, epidermal growth factor (EGF) help tumor cells survive, VEGF and IL-8 promote angiogenesis, M2 macrophages, and MDSCs antagonize inflammatory responses, IL-10, TGF-β, C-C motif chemokine ligand (CCL17) inhibits tumor immune function, and TGF-β and MMP promote tumor metastasis (86, 87). Here, TGFB1 is linked to neoplasm.