STAT3 and cancer: Celastrol It has anti-oxidation, anti-rheumatoid, anti-Alzheimer’s, and anti-cancer properties, induces cell cycle arrest, up-regulates the expression of caspase-3, caspase-8, and Bax, down-regulates the expression of Bcl-2 to induce apoptosis, inhibits the expression of STAT3 and IL-6, and inhibits the properties of CSCs.