miR-141 is a specific tumor suppressor miRNA, ZEB2 is a target of miR-141 and is an important regulator in EMT and CSC, and honokiol, a natural product of magnolia plants, mainly used to eliminate chest and abdominal congestion, calm the central nervous system, anti-inflammatory and antibacterial, can be mediated by miR-141. Here, ZEB2 is linked to neoplasm.