Sinomenine hydrochloride is naturally extracted from the rhizomes of caprophyaceae, and can inhibit breast cancer metastasis because it can inhibit EMT and CSC properties while inhibiting the activation of NF-kB and the expression of MMP, reversing endogenous and exogenous EMT, reversing the inflammatory microenvironment, and then inhibiting human Metastasis of glioblastoma cells (159, 160). Here, NFKB1 is linked to breast carcinoma.