VEGF, as a vascular endothelial growth factor, can stimulate tumor angiogenesis, and andrographolide, As a kind of diterpenoid lactone, Andrographolide is good for the gallbladder, protects the liver, regulates the body’s immunity, and is used in meningitis, pneumonia, upper respiratory tract infection and has anti-tumor effect, inhibits angiogenesis through the VEGF pathway and inhibits the expression of COX-2 at the protein and mRNA levels. This evidence concerns the gene PTGS2 and neoplasm.