IL10 and neoplasm: Furthermore, it was found to have certain associations with macrophages and NK cells, mainly by isolating an amino acid, cysteine, which is essential for T cell activation, MDSC polarizes macrophages to a tumor-promoting phenotype, and also Transfers macrophages to an M2 phenotype with immunosuppressive features and low IL-12 production (58), while inhibiting NK-mediated tumor cell lysis (59–61), production of the immunosuppressive cytokines IL-10 and TGF -β affects NK cell function.