CALR and cancer: ICD is induced by the stress effect of the lateral endoplasmic reticulum, with exposure to the release of numerous damage-associated molecular patterns (DAMPs), including calreticulin (CRT), secretion of adenosine triphosphate (ATP), type I interferon (IL-1) and high migration group box 1 (HMGB1), the effects of these processes on tumors have some prognostic value and a powerful adjuvant effect on dying cancer cells (16).