CASP3 and hepatocellular carcinoma: Atractylodes ketone derived from atractylodes atractylodes or atractylodes atractylodes, is widely used for liver protection, antibacterial, and antiviral, can reduce mitochondrial membrane potential, increase ROS level, inhibit the expression of Bcl-2, promote the expression of Bax and caspase-3 to induce hepatocellular carcinoma apoptosis, and inhibit EMT to inhibit the metastasis and invasion of hepatocellular carcinoma (33).