Similarly, resveratrol inhibited STAT3 inactivation during M2 polarization of macrophages in mouse lung cancer xenografts (101), in addition, resveratrol effectively inhibited lung metastasis of breast cancer, which effectively Inactivation of STAT3 blocks the function of regulatory B cells and blocks the production of TGF-β (102). Here, TGFB1 is linked to breast carcinoma.