A newly developed curcumin-like compound (2E,6E)-2,6-bis(2,3-dimethoxy benzyl aniline)cyclohexanone (DMCH) in colon cancer HT29 and SW620 cell lines Analysis of the apoptotic panel of the group showed that Bax protein expression was up-regulated, and it was found that more apoptotic cells were observed in the treated SW620 cell line than in the HT29 cell line (19). Here, BAX is linked to malignant colon neoplasm.