NFKB1 and breast cancer: Sinomenine hydrochloride is naturally extracted from the rhizomes of caprophyaceae, and can inhibit breast cancer metastasis because it can inhibit EMT and CSC properties while inhibiting the activation of NF-kB and the expression of MMP, reversing endogenous and exogenous EMT, reversing the inflammatory microenvironment, and then inhibiting human Metastasis of glioblastoma cells (159, 160).