Simultaneous activation of the MGL receptor (by the Tn antigen) and the DC-SIGN receptor (by fucosylated antigens) on tumor-associated macrophages (TAMs) triggered the generation of IL-10 with a concomitant decrease in IL-6, leading to a “tolerogenic tumor microenvironment”, incapable of mounting a potent anti-PDAC response (Figure 1B) (33, 34). This evidence concerns the gene IL6 and neoplasm.