BRCA2 and breast cancer: Briefly, the MBC series included four cases (26.7%) with germline pathogenic variants in BRCA1 (two), BRCA2 (one) and PALB2 (one) genes, mean age at BC diagnosis was 63.0 years (range 36-88 years) and median follow-up was 3.0 years (range 1-10 years).