This is a more cost-effective approach and in addition provides information on the deficient dMMR protein, gaining insight into the possible mechanism of the disease, whether likely sporadic (associated with MLH1 protein loss through MLH1 promoter methylation, and BRAFV600E pathogenic variants) or due to hereditary Lynch syndrome pathogenic variants (MSH2, MSH6, MLH1, or PMS2) (237–239). Here, MLH1 is linked to Lynch syndrome.