PACC1 and melanoma: RAS is the most frequently mutated oncogene in human malignancies and a key kinase in the RAS-RAF-MAPK signaling pathway, as well as taking part in other tumor-related signaling pathways such as PI3K/AKT, PAC, and PAL signaling pathways (5).Mutations in the AKT family have been found in up to 43-60% of melanoma cases (6).