To evaluate exosome induced changes in the mRNA profile of tumor cells in vitro, UD-1 cells were co-incubated with exosomes from patients before and after therapy and their expression of E-cadherin and vimentin as well as the EMT-related transcription factors TWIST, SNAIL and SLUG was measured by RT-qPCR. The gene discussed is SNAI2; the disease is neoplasm.