In addition, TQ treatment has been found to lead to the appearance of cleaved caspase-3, -9, and the active components of poly ADP ribose polymerase (PARP) in pancreatic cancer cells, activate the upstream events of the caspase cascade, release cytochrome c, and induce apoptosis through the mitochondria pathway. The gene discussed is CASP3; the disease is familial pancreatic carcinoma.