MAPK8 and familial pancreatic carcinoma: First, TQ can downregulate the expression of mucin 4 (MUC4) through the proteasome pathway, which leads to the activation of c-jun NH2 terminal kinases (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) pathways in pancreatic cancer cells, thereby inducing apoptosis.