The TQ analogs TQ-4A1, TQ-5A1, and TQ-2G are more effective than the parental TQ in the apoptosis of pancreatic cancer cells and can downregulate the DNA-binding effect of NF-κB, inhibit the activity of NF-κB and its downstream proteins such as survivin, Bcl-xl, and XIAP, and affect the cell cycle (G2/M cell cycle arrest). Here, NFKB1 is linked to familial pancreatic carcinoma.