AFP and cancer: Adjusting for sex, age, comorbidities, and etiology of cancer, the multivariate analysis indicated that early AFP response (HR, 0.490; 95% CI, 0.308-0.780; P = 0.003) and ECOG performance status of 1 or 2 (HR, 2.201; 95% CI, 1.240-3.907; P = 0.007) were independent prognostic factors associated with longer OS (Table 3).