MAPK8 and neoplasm: Anti-tumor: Suppression of tumor growth and angiogenesis via inhibition of COX-2, SDF1, VEGF, and MMP9 expression and down-regulation of JNK/ERK/IκB/NFκB signaling pathway inLLC tumors, as well as inhibition of macrophage polarization (20) and monocyte recruitment (21, 22).