High CXCL16 expression was associated with aggressive pathologic phenotypes, the higher TNM staging and lymph node metastasis in 77 patients with papillary thyroid cancers, in 25 patients with thyroid follicular adenomas, and 81 - with normal thyroid tissues from the SNUH cohort (51). The gene discussed is CXCL16; the disease is metastatic malignant neoplasm in the lymph nodes.