S100A4 and breast cancer: Pro-tumor: Promotion of tumor growth via up-regulation of pro-tumor genes, M2-signature genes in TAMs and enhancing TAM infiltration in lymphoma (34). Supporting tumor development through activation of S100A4-PPAR-γ pathway in TAMs in breast cancer and fibrosarcoma (35).Increasing of tumor growth via promotion of TAM infiltration in tumor in breast cancer (36).