Pro-tumor: Promotion of tumor growth via up-regulation of pro-tumor genes, M2-signature genes in TAMs and enhancing TAM infiltration in lymphoma (34). Supporting tumor development through activation of S100A4-PPAR-γ pathway in TAMs in breast cancer and fibrosarcoma (35).Increasing of tumor growth via promotion of TAM infiltration in tumor in breast cancer (36). This evidence concerns the gene S100A4 and lymphoma.