IDH3A and central nervous system cancer: Based on the 2016 WHO classification system of the CNS, glioma could be classified as followed: lower grade glioma (LGG) with isocitrate dehydrogenase (IDH) mutation with or without 1p/19q-codel, LGG with IDH-wildtype subtype, glioblastoma multiforme (GBM) with IDH mutation or not (54).