PTEN and clear cell adenocarcinoma: The common mutations in HGSOC were TP53 (96%), BRCA1/2 (23%) and HRD (homologous recombination defect) mutation (50%); The common mutations in clear cell carcinoma are PIK3CA, ARD1A, PTEN and microsatellite instability (MSI); Common mutations in endometrioid carcinoma are CTNNB1, ARID1A, PTEN, MSI; The common mutations in mucinous carcinoma are KRAS, HER2 and CDKN2A mutations; In LGSOC, mutations such as BRAF, KRAS, NRAS, ERBB2 and PIK3CA are more common (Schachter, 2005).