GPX4 and brain ischemia: Compared with rats in the control group, Naotaifang treatment increased the expression levels of SLC7A11, GPX4, and GSH, as well as the number of Nissl bodies, inhibited ferroptosis through TFR1/DMTI and SCL7A11/GPX4 signaling pathways, thereby improving acute cerebral ischemic injury and neurological function in patients with cerebral ischemia (Lan et al., 2020).