In the present study, first, our results showed that CUMS treatment for 3–5 weeks induced depression-like behavior and body weight loss, accompanied by a series of biochemical changes in the mouse hippocampus presenting a reduced number of astrocytes, decreased protein levels of BDNF, activated necroptosis kinases, and upregulated inflammatory cytokines. The gene discussed is BDNF; the disease is depressive symptom measurement.