Given the prognostic value of ANRGs evaluated by univariate Cox analysis, we established a nine-gene risk score signature, with NQO1, ETV4, BSG, HMGA1, DAP3, PBK, BIRC5, PLK1, and EZH2, by means of the scoring algorithm to predict HCC patient prognosis. Here, PLK1 is linked to hepatocellular carcinoma.