Zheng et al. reported that the enhanced expression of ETV4 by HBx may stimulate the metastasis of HCC (Zheng et al., 2022) The literature showed that the interaction between ETV4 and YAP conferred a growth advantage to HCC and had a protumorigenic role (Xu et al., 2022). The gene discussed is ETV4; the disease is hepatocellular carcinoma.