Given the prognostic value of ANRGs evaluated by univariate Cox analysis, we established a nine-gene risk score signature, with NQO1, ETV4, BSG, HMGA1, DAP3, PBK, BIRC5, PLK1, and EZH2, by means of the scoring algorithm to predict HCC patient prognosis. This evidence concerns the gene HMGA1 and hepatocellular carcinoma.