Moreover, SGLT2 inhibitors attenuate myocardial oxidative stress via activation of the Nrf2/ARE signaling pathway, and protect cardiomyocytes from hyperglycemia-induced damage by inhibiting NADPH oxidase-mediated oxidative stress (Li et al., 2019; Xing et al., 2021). This evidence concerns the gene SLC5A2 and Hyperglycemia.