MAPK8 and cancer: For example, phosphorylation of Nur77 by protein kinase B (AKT) promotes its nuclear shuttling, resulting in the promotion of cancer cell proliferation and invasion, while its phosphorylation by c-Jun N-terminal kinase (JNK) involves the apoptosis in certain cancer cells (Han et al., 2006; Bourhis et al., 2008; Bliss et al., 2012).