On the other hand, the pro-apoptotic effect of Nur77 involves its translocation from the nucleus to mitochondria, where it interacts with Bcl-2 and converts Bcl-2 from a survival to a killer of cancer cells (Lin et al., 2004; Kolluri et al., 2008; Zhou et al., 2014; Liu et al., 2017). Here, NR4A1 is linked to cancer.