CDK4 and breast cancer: In addition, since 17 genes i.e. APP, AR, CDK4, CYP19A1, FGFR2, GRM1, IGF1R, LYN, MDM2, MDM4, NR3C1, PDGFRB, PRCP, PTPN1, RET, SRC, and STAT3 were observed to have a significant role in disease prognosis, it can be speculated that the above-modulated proteins are primarily concerned with breast cancer management with diosgenin treatment.