CDK4 and breast cancer: In addition, three pathways i.e., PI3K-Akt (modulated five genes i.e., CDK4, MDM2, PDGFRB, IGF1R, and FGFR2), Ras (modulated three genes i.e., PDGFRB, IGF1R, and FGFR2), and MAPK (modulated three genes i.e., PDGFRB, IGF1R, and FGFR2) signaling pathways associated to HER2 positive breast cancer were modulated.