Since breast cancer progression is closely linked to EGFR tyrosine kinase signal; it can be speculated that diosgenin-mediated Rap1 signal could attenuate tumor invasion and metastasis; was observed to be modulated via the modulation of three genes i.e., PDGFRB, IGF1R, and FGFR2. The gene discussed is IGF1R; the disease is breast cancer.