In addition, pathways in cancer; hsa05200, EGFR tyrosine kinase inhibitor resistance; hsa01521 prostate cancer; hsa05215, viral carcinogenesis; hsa05203, and PI3K-Akt signaling pathway; hsa04151 were traced as the top five lead hub pathways modulated within diosgenin-targets-pathways interactions. This evidence concerns the gene AKT1 and prostate cancer.