POMGNT1 and muscle-eye-brain disease: Muscular dystrophy due to hypoglycosylation of α-DG is an autosomal recessive disorder in which muscle-eye-brain disease (MEB, or muscular dystrophy-muscular dystrophy glycosis type 3A) is primarily caused by homozygous or compound heterozygous mutations in the POMGNT1 gene (Mohammadi et al., 2021).