Combined with the enrichment analysis, we provoked the hypothesis that the GAD1, ALDH1B1, and FOXP2 genes functioned with NK1R in terms of angiogenesis, EMT, collagen deposition, and inflammation, while blockade of NK1R may be therapeutic not only for depression but also for the diabetic non-healing wound. The gene discussed is ALDH1B1; the disease is major depressive disorder.