CXCR3 and type 2 diabetes mellitus: However, the level of CXCR3 showed a significant decrease in C03 subset, C21 subset, and C27 subset in the T2D-DN group, while the CD39 expression was significantly increased in C21 NaiveCD4 T cell of T2D-DN patients, compared with those in T2D group (Figures 2I, J).