When it comes to HMGN2, MLLT11, PCSK1N and RGS16, the diagnostic performance of them for NEPC has not been shown, deacetylation of high mobility group nucleosomal binding domain 2 (HMGN2) enhances STAT5A transcriptional activity, thereby regulating prolactin induced gene transcription and breast cancer growth (74, 75). Here, PCSK1N is linked to breast cancer.