GCG and metabolic dysfunction-associated steatohepatitis: Besides genetic defects and pharmacological interventions to inhibit glucagon signaling, hepatic disorders (e.g., NAFLD and NASH (9, 22, 23)) and certain metabolic conditions (e.g., obesity (24, 25), T2DM (22)) have been associated with impaired glucagon signaling and hence disrupted LACA (26, 27).