1) Patients with NAFLD, despite having normal glucose tolerance are characterized by reduced incretin effect, fasting hyperglucagonaemia and impaired handling of ingested glucose. Study emphasizes the role of NAFLD in metabolic dysregulation and suggests an important role for the liver in the regulation of glucagon secretion. 2) In spite of fasting hyperglucagonemia, patients with cirrhosis suppressed glucagon during both OGTT and IIGI, indicating preserved alpha cell sensi-tivity to GLP-1. The gene discussed is GCG; the disease is Cirrhosis.