IRS4 and acute lymphoblastic leukemia: The minor allele for the six PTC-specific SNVs were either totally absent (BRAF c.1799T>A (p.Val600Glu) and IRS4 c.605A>G (p.Lys202Arg) or present in less than 1% in the world (ALL), African (AFR), American (AMR), East Asian (EAS), European (EUR) and South Asian (SAS) populations.