In addition, whether other hypothalamic neuropeptides with known effects in both feeding control and the modulation of nociceptive processing, such as orexin, oxytocin (OT), neuropeptide Y (NPY), and pituitary adenylate cyclase activating protein (PACAP) (53), are also important players in the association between obesity and headache remains to be elucidated. This evidence concerns the gene HCRT and Headache.