This study aimed to investigate the correlation between the genetic polymorphisms of Ca2+ transporter gene (ITPR2, VDAC1) and its related chaperones (HSPA5, HSPA9, SIGMAR1, CANX, PPID) and NAFLD in Chinese population, to provide new ideas for further exploring the genetic susceptibility mechanism of NAFLD. This evidence concerns the gene ITPR2 and metabolic dysfunction-associated steatotic liver disease.