When included in the same regression model and following multivariate analysis and adjustment of established risk factors, only adiponectin and IGFBP-2 remained significantly and independently associated with future prediabetes and T2D in women, while only IGFBP-1 remained associated with future prediabetes and T2D in men (Table 3). The gene discussed is IGFBP2; the disease is prediabetes syndrome.