When included in the same regression model and following multivariate analysis and adjustment of established risk factors, only adiponectin and IGFBP-2 remained significantly and independently associated with future prediabetes and T2D in women, while only IGFBP-1 remained associated with future prediabetes and T2D in men (Table 3). This evidence concerns the gene IGFBP1 and prediabetes syndrome.