After adjustment for known risk factors, significant ORs for future T2D were obtained for the lowest quartiles of adiponectin (OR:29.42), IGFBP-2 (OR:9.52) and IGFBP-1 (OR:5.41), and for the highest quartile of IGF-I (OR:3.79). Here, IGFBP1 is linked to type 2 diabetes mellitus.