Odds ratios (ORs) for decreasing baseline values of IGFBP-2, adiponectin and IGFBP-1 and increasing baseline values of IGF-I and IGF-II in subjects having normal glucose tolerance (NGT) at baseline in the association to development of prediabetes and type 2 diabetes at follow-up compared to remaining NGT. The gene discussed is IGFBP2; the disease is prediabetes syndrome.