Thus, this longitudinal study performed in a well-described large cohort confirms that in normoglycemic women, low levels of adiponectin and IGFBP-2 are predictors of T2D (18, 21, 22, 26–28), whereas in normoglycemic men, low levels of IGFBP-1 predict future T2D (16). The gene discussed is IGFBP1; the disease is type 2 diabetes mellitus.