Thus, this longitudinal study performed in a well-described large cohort confirms that in normoglycemic women, low levels of adiponectin and IGFBP-2 are predictors of T2D (18, 21, 22, 26–28), whereas in normoglycemic men, low levels of IGFBP-1 predict future T2D (16). This evidence concerns the gene IGFBP2 and type 2 diabetes mellitus.