A preclinical study on experimental T1DM rats injected with 65 mg/kg intraperitoneal single dose of streptozotocin (STZ) found decreased levels of asprosin, PKA, and transforming growth factor-β (TGF-β), however, elevated AMPK and protein kinase B (AKT) levels in the liver under aerobic exercise training (50). This evidence concerns the gene AKT1 and type 1 diabetes mellitus.