The resistin levels of patients with thyroid dysfunction after treatment were significantly lower than those before treatment (MD = 1.00, 95% CI = 0.34–1.65, P = 0.003), especially in patients with hyperthyroidism (MD = 2.16, 95% CI = 1.00–3.32, P = 0.0003). Here, RETN is linked to hyperthyroidism.