Comparing the above-obtained eight pathways from the TP network, we found that there were four overlapping pathways between them, including the AGE-RAGE signaling pathway in diabetic complications (hsa04933), HIF-1 signaling pathway (hsa04066), proteoglycans in cancer (hsa05205), and African trypanosomiasis (hsa05143). The gene discussed is RENBP; the disease is human African trypanosomiasis.