Univariate analysis revealed that the following variables were significantly associated with DR: age, sex, hypertension, CVD, stroke, antihypertensive drugs, statins, antiplatelet drugs, antidiabetic drugs (insulin, TZD, AGI, DPP-4i, GLP-1 RAs, Met), duration, BMI, SBP, SII, TBIL, TC, Cr, LDL-C, Alb, HbA1c, FBG, and eGFR (Table 2). The gene discussed is INS; the disease is Stroke.