The downregulated genes were mainly enriched in NF-kappa B (NF-κB) signaling pathway, Kaposi sarcoma-associated herpesvirus infection, pathways in cancer, Notch signaling pathway, microRNAs in cancer, breast cancer, arrhythmogenic right ventricular cardiomyopathy, Th1 and Th2 cell differentiation, chemical carcinogenesis-DNA adducts, and thyroid cancer. The gene discussed is NFKB1; the disease is thyroid gland carcinoma.