Another study in canine gliomas determined the nature of the infiltration, differentiating between CD3 T cells and those positive for the Forkhead box protein P3 (FOXP3), a regulator of Treg cell gene expression, finding similar results with generally low numbers of Treg cells, although higher FOXP3 densities were found in high grade tumors (95). The gene discussed is FOXP3; the disease is glioma.