TYRP1 and melanoma: Whereas, SOX10, S100, HMB-45 and Melan A are normally used as markers of human melanoma, (35, 36) common markers used to identify canine melanomas are Melan-A, PNL2, and tyrosinase related protein 1 and 2 (TRP-1 and TRP-2) (29, 30).