A case of leukemia in a 17-year-old was also described, due to the unusual pattern of presentation with bilateral symmetrical retro-areolar mass. Papillary cancer is said to be the second type of breast cancer in males, and leukemia is known to be metastatic to the male breast although the most common is from the prostate. All but one of the patients with invasive ductal carcinoma as well as the patient with papillary cancer were hormone receptor-positive and HER2-negative. This evidence concerns the gene ERBB2 and leukemia.