Another study performed scRNA-Seq and Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-Seq) to illustrate the immune landscape using samples from patients and mice with newly diagnosed GBM and recurrent GBM, and the results revealed a large difference in myeloid compartments, including TAMs, DCs, natural killer (NK) cells, CD8+ T cells, and B cells (Pombo Antunes et al., 2021). Here, CD8A is linked to glioblastoma.