First, through the Brain Tumor Immune Micro Environment (Brain TIME) analysis, we found that FCGR2B in microglia and infiltrating monocyte-derived macrophages (MDMs) was more highly expressed in IDH wild-type (IDH_WT) glioma tissues or brain metastases (BrMs) than in non-tumor tissues (Figure 5A). Here, FCGR2B is linked to central nervous system cancer.