High-risk patients were closely related to myeloid leukocyte activation, inflammatory response such as Chemokine, Cytokine-cytokine receptor interaction, Interleukin-6 production, Leukocyte transendothelial migration, Toll like receptor, Apoptosis and Interferon gamma, and tumor-related signaling pathways such as IL6-JAK-STAT3, MAPK, VEGF, Wnt, PI3K-AKT-mTOR, KRAS, NF-κB and P53. The gene discussed is VEGFA; the disease is neoplasm.