By integrating data from the GTEx database, we compared the ZNF281 expression levels in cancer and their normal adjacent tissues, and ZNF281 was significantly expressed higher in 11 cancer types, including BLCA, BRCA, CHOL, COAD, ESCA, HNSC, KIRC, LIHC, LUAD, PRAD, and STAD. The gene discussed is ZNF281; the disease is cancer.