Several studies have investigated that XRCC1 gene polymorphisms (Arg399Gln and Arg194Trp) increase the risk of HNSCC (Choudhury et al., 2014; Dutta et al., 2020; Kabzinski et al., 2021) and suggested that high XRCC1 protein expression is associated with poorer survival in patients with HNSCC(Ang et al., 2011). Here, XRCC1 is linked to head and neck squamous cell carcinoma.