IGSF10 and cancer: Interestingly, from the heatmap (Figure 8A), we can observe that nearly all immune checkpoint genes have been related to IGSF10 in most cancer types, with the exception of CESC, LUSC, MESO, SARC, UCEC, and UVM, majority of immune checkpoint genes have been positively related to IGSF10 in all kinds of tumors.