We observed that the IGSF10 was significantly reduced in the early tumor stages of 14 cancers (Figure 2), inclusive of BLCA, BRCA, COAD, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, and UCEC, suggesting that IGSF10 may have vital guiding magnitude for the early diagnosis of sufferers with these kinds of tumors. The gene discussed is IGSF10; the disease is cancer.