We observed that the IGSF10 was significantly reduced in the early tumor stages of 14 cancers (Figure 2), inclusive of BLCA, BRCA, COAD, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, READ, STAD, THCA, and UCEC, suggesting that IGSF10 may have vital guiding magnitude for the early diagnosis of sufferers with these kinds of tumors. This evidence concerns the gene IGSF10 and neoplasm.