IGSF10 and adrenal cortex carcinoma: Figure 12B showed the correlation results between IGSF10 mRNA expression and IGSF10 methylation levels in various tumors. Methylation of IGSF10 was negatively correlated with IGSF10 mRNA expression in PCPG, PRAD, PAAD, MESO, and UCS etc. The association between methylation of IGSF10 and prognosis in pan-cancer was further analyzed. As shown in Figure 12C, patients with hypermethylation of IGSF10 had a good prognosis in KIRP, LGG and PAAD, but the opposite trend in ACC.