Thereinto, IGSF10 levels were downregulated in Adrenocortical carcinoma (ACC), BLCA, BRCA, Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), COAD, ESCA, HNSC, KICH, KIRC, KIRP, LIHC, LUAD, LUSC, Ovarian serous cystadenocarcinoma (OV), PRAD, READ, Skin cutaneous melanoma (SKCM), STAD, Testicular germ cell tumors (TGCT), THCA, and UCEC. The gene discussed is IGSF10; the disease is cutaneous melanoma.